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Dr Zhang Xiaomin MD PhD
Department Uveitis & Ocular Immunology
Languages Chinese & English
Conditions treated Uveitis, scleritis
Procedures performed Comblined therapy with steroids, immunosuppressants, ocular sustained-release implants, and biological agents
Research interests Novel therapies for uveitis, pathogenesis and genetics of uveitis, and mesenchymal stem cell based therapy for ocular diseases.
 
Education and training 　
2005-2006 Post-doc  Paris University 12th
2001-2004 PhD Tianjin Medical University
1998-2001 Master degree Weifang Medical College
1993-1998 Bachelor degree Weifang Medical College
　 　 　
　 　
Professional memberships Board member of Ocular Immunology Group of Ophthalmological Society, Chinese Medical Association 
　 　 Board member of Uveitis & Ocular Immunology Group of Ophthalmological Society, Chinese Medical Doctoral Association 
　 　 Board member of Eye Health Professional Committee, Chinese Aging Well Association 
　 　 Board member Youth Committee of Ophthalmological Society, China International Exchange and Promotive Association for Medical and Health Care  
　 　 Board member of Immunology and Infection Group of Ophthalmological Society, China Medical Women's Association 
　 　 Board member of Youth Committee of Ophthalmological Society, Chinese Medical Doctoral Association 
　 　 Editorial board member of Chinese Journal of Experimental Ophthalmology 
　 　 Communication Editorial board member of Chinese Journal of Ocular Fundus Diseases
　 　 Board member of Clinical Data and Biobank Society of Chinese Research Hospital Association
Selected publications 　
2019 J Ophthalmol Long-Term Clinical Outcomes after Mix and Match Implantation of Two Multifocal Intraocular Lenses with Different Adds. Jiang Y, Bu S, Tian F, Liang J, Wang T, Xing X, Zhang H, Zhang X. https://doi.org/10.1155/2019/6789263
　 　 　
2019 Aging (Albany NY) HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration.  Sun S, Cai B, Li Y, Su W, Zhao X, Gong B, Li Z, Zhang X, Wu Y, Chen C, Tsang SH, Yang J, Li X. https://doi.org/10.18632/aging.102039
　 　 　
2019 Int Ophthalmol Mechanism of interaction between ocular and nasal neurogenic inflammation in allergic rhinoconjunctivitis. Gao XW, Zhang XM, Liu HY, Wang SS, Dong HJ. https://doi.org/10.1007/s10792-018-01066-5
　 　 　
2018 Graefe's Arc Clin Exp Ophthal Effects of Mesenchymal Stem Cells and Their Exosomes on the Healing of Large and Refractory Macular Holes. Zhang X, Liu J, Yu B, Ma F, Ren X, Li X. https://doi.org/10.1007/s00417-018-4097-3
　 　 　
2018 Curr Mol Med Mesenchymal stem cells inhibited dendritic cells via the regulation of STAT1 and STAT6 phosphorylation in experimental autoimmune uveitis. Dong L, Chen X, Shao H, Bai L, Li X, Zhang X. https://doi.org/10.2174/1566524018666180207155614
　 　 　
2018 Hum Genet Application of CRISPR/Cas9 technologies combined with iPSCs in the study and treatment of retinal degenerative diseases. Cai B, Sun S, Li Z, Zhang X, Ke Y, Yang J, Li X. https://doi.org/10.1007/s00439-018-1933-9
　 　 　
2018 JAMA Ophthalmol Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease. Yang P, Zhong Y, Du L, Chi W, Chen L, Zhang R, Zhang M, Wang H, Lu H, Yang L, Zhuang W, Yang Y, Xing L, Feng L, Jiang Z, Zhang X, Wang Y, Zhong H, Jiang L, Zhao C, Li F, Cao S, Liu X, Chen X, Shi Y, Zhao W, Kijlstra A. https://doi.org/10.1001/jamaophthalmol.2018.2664
　 　 　
2018 Invest Ophthalmol Vis Sci Local S100A8 levels correlate with recurrence of experimental autoimmune uveitis and promote pathogenic T cell activity. Yun J, Xiao T, Zhou L, Beuerman RW, Li J, Zhao Y, Hadayer A, Zhang X, Sun D, Kaplan HJ, Shao H. https://doi.org/10.1167/iovs.17-23127 
　 　 　
2017 Stem Cell Res Ther Bringing the age-related macular degeneration high-risk allele age-related maculopathy susceptibility 2 into focus with stem cell technology. Sun S, Li Z, Glencer P, Cai B, Zhang X, Yang J, Li X. https://doi.org/10.1186/s13287-017-0584-4
　 　 　
2017 Sci Rep Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. Bai L, Shao H, Wang H, Zhang Z, Su C, Dong L, Yu B, Chen X, Li X, Zhang X. https://doi.org/10.1038/s41598-017-04559-y
　 　 　
2017 BMC Ophthalmol Characteristics of syphilitic uveitis in northern China. Zhang X, Du Q, Ma F, Lu Y, Wang M, Li X. https://doi.org/10.1186/s12886-017-0491-6
　 　 　
2016 Int J Ophthal Therapeutic effects of mesenchymal stem cells administered at later phase of recurrent experimental autoimmune uveitis. Pingting Zhao, Lingjun Zhang, Hui Shao, Lingling Bai, Bo Yu, Chang Su, Lijie Dong, Xun Liu, Xiaorong Li, Xiaomin Zhang. https://doi.org/10.18240/ijo.2016.10.03
　 　 　
2016 Scientific Reports Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1. Yu B, Shao H, Su C, Jiang Y, Chen X, Bai L, Zhang Y, Li Q, Zhang X, Li X. https://doi.org/10.1038/srep34562
　 　 　
2016 Stem Cell Dev CD73 pathway contributes to the immunosuppressive ability of mesenchymal stem cells (MSCs) in intraocular autoimmune responses. Chen X, Shao H, Zhi Y, Xiao Q, Su Chang, Dong L, Liu X, Li X, Zhang X. https://doi.org/10.1089/scd.2015.0227
　 　 　
2016 J Leukoc Biol Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis. Zhang L, Bell BA, Yu M, Chan CC, Peachey NS, Fung J, Zhang X, Caspi RR, Lin F.  https://doi.org/10.1189/jlb.3A0415-157R
　 　 　
2016 Stem Cells Int Induced Pluripotent Stem Cells and Outer Retinal Disease. Yang J, Cai B, Glencer P, Li Z, Zhang X, Li X. https://doi.org/10.1155/2016/2850873
　 　 　
2016 Retina INTRAVITREAL CONBERCEPT (KH902) FOR SURGICAL TREATMENT OF SEVERE PROLIFERATIVE DIABETIC RETINOPATHY. Su L, Ren X, Wei H, Zhao L, Zhang X, Liu J, Su C, Tan L, Li X. https://doi.org/10.1097/IAE.0000000000000900
　 　 　
2015 Sci Rep α-Melanocyte-stimulating hormone prevents glutamate excitotoxicity in developing chicken retina via MC4R-mediated down-regulation of microRNA-194. Zhang Y, Bo Q, Wu W, Xu C, Yu G, Ma S, Yang Q, Cao Y, Han Q, Ru Y, Liu X, Hua Wei R, Wang FE, Zhang X, Li X. https://doi.org/10.1038/srep15812
　 　 　
2015 Cell Tissue Res PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy. Dong L, Nian H, Shao Y, Zhang Y, Li Q, Yi Y, Tian F, Li W, Zhang H, Zhang X, Wang F, Li X. https://doi.org/10.1007/s00441-014-2104-5
　 　 　
2015 Int J Ophthal Achromatopsia Caused by Novel Missense Mutations in the CNGA3 Gene. Chen X, Huang H, Chen Y, Dong L, Li X, Zhang X. https://doi.org/10.3980/j.issn.2222-3959.2015.05.10
　 　 　
2015 Int J Ophthal Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells. Yuan L, Li G, Ren X, Li X, Zhang X. https://doi.org/10.3980/j.issn.2222-3959.2015.04.03
　 　 　
2014 Invest Ophthalmol Vis Sci Long-term therapeutic effects of mesenchymal stem cells compared with dexamethasone on recurrent experimental autoimmune uveitis of rats. Zhang L, Zheng H, Shao H, Nian H, Zhang Y, Bai L, Su C, Liu X, Dong L, Li X, Zhang X. https://doi.org/10.1167/iovs.14-14788
　 　 　
2014 Int J Mol Sci Therapeutic effect of bone marrow mesenchymal stem cells on laser-induced retinal injury in mice. Jiang Y, Zhang Y, Zhang L, Wang M, Zhang X, Li X. https://doi.org/10.3390/ijms15069372
　 　 　
2014 Int J Mol Sci Exosomes Derived from Mesenchymal Stem Cells. Yu B, Zhang X, Li X. https://doi.org/10.3390/ijms15034142
　 　 　
2014 PLoS One α-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes. Zhang L, Dong L, Liu X, Jiang Y, Zhang L, Zhang X, Li X, Zhang Y. https://doi.org/10.1371/journal.pone.0093433
　 　 　
2013 Graefes Arch Clin Exp Ophthalmol Reconstruction of orbital defects by implantation of antigen-free bovine cancellous bone scaffold combined with bone marrow mesenchymal stem cells in rats. Zhao J, Yang C, Su C, Yu M, Zhang X, Huang S, Li G, Yu M, Li X. https://doi.org/10.1007/s00417-013-2300-0
　 　 　
2013 Clin Exp Immunol The Effect of Mesenchymal Stem Cells on Dynamic Changes of T Cell Subsets in Experimental Autoimmune Uveoretinitis. Li G, Yuan L, Ren X, Hong N, Zhang L, Zhong CH, Li X, Zhang X. https://doi.org/10.1111/cei.12080 
2013 Int Immunopharmacol Effects of human umbilical cord-derived mesenchymal stem cells on anterior chamber-associated immune deviation. Zhang Y, Zhang M, Zhao S, Li X, Jia Z, Zhang L, Zhong CH, Zhang X. https://doi.org/10.1016/j.intimp.2012.11.007 
　 　 　
2012 Exp Eye Res Immunomodulatory effects of mesenchymal stem cells in a rat corneal allograft rejection model. Jia Z, Jiao C, Zhao S, Li X, Ren X, Zhang L, Han ZC, Zhang X. https://doi.org/10.1016/j.exer.2012.06.008 
　 　 　
2011 Invest Ophthalmol Vis Sci Mesenchymal Stem Cells Ameliorate Experimental Autoimmune Uveoretinitis by Comprehensive Modulation of systemic autoimmunity. Zhang X, Ren X, Li G, Jiao C, Zhang L, Zhao S, Wang J, Han ZC, Li X. https://doi.org/10.1167/iovs.10-6334
　 　 　
2010  J Tissue Eng Regen Med Utilization of human limbal mesenchymal cells as feeder layers for human limbal stem cells cultured on amniotic membrane. Zhang X, Sun H, Li X, Yuan X, Zhang L, Zhao S. https://doi.org/10.1002/term.216
　 　 　
2009 Ann Ophthalmol (Skokie) Microstructure of the cornea in high myopia with confocal microscope through focusing in vivo. Zhao S, Zhao J, Li X, Wei R, Zhang X, Deng Z. https://doi.org/10.1016/j.ajo.2009.03.032
2009 Stem Cell Rev Role of mesenchymal stem cells in immunological rejection of organ transplantation. Zhang X, Jiao C, Zhao S. https://doi.org/10.1007/s12015-009-9076-y
2005 Exp Eye Res Comparison of cell-suspension and explant culture of rabbit limbal epithelial cells. Zhang X, Sun H, Tang X, Ji J, Li X, Sun J, Ma Z, Yuan J, Han ZC. https://doi.org/10.1016/j.exer.2004.09.005
Fundings 　 　
81870651  01/01/2019-01/12/2022 Application of sustained-release preparation of MSC-derived exosomes loaded with rapamycin in autoimmune uveitis. National Natural Science Foundation Grant; 570,000 RMB; PI

01/05/2016-30/04/2017 Therapeutic potential of Mab2F1, an inhibitor of Wnt pathway, in experimental autoimmune uveitis, MMAAP foundation funding, $ 60,000; PI

8167060814  01/01/2017-01/12/2020 Therapeutic potential of the monoclonal antibody Mab2F1 in experimental autoimmune uveitis by blocking Wnt pathway. National Natural Science Foundation Grant; 570,000 RMB; PI

15JCZDJC35600  01/04/2015-31/03/2018 Investigation of the therapeutic effect of MSC derived exosomes on uveitis. Tianjin Municipal Science Foundation Grant; 200,000 RMB; PI

814228012  01/01/2015-31/12/2016 Local inhibition of complement to improve MSC viability. National Natural Science Foundation Grant; 200,000 RMB; co-PI

81371005   01/01/2014-12/31/2017 The Mechanisms of Transforming Growth Factor β Transgenic Mesenchymal Stem Cells in Suppression of Experimental Autoimmune Uveitis; National Natural Science Foundation Grant; 700,000 RMB; PI

81371037  01/01/2014-31/12/2014 DNA/miRNA Methylation regulating mechanisms underlying differentiation of hESCs into RPE cells. National Natural Science Foundation Grant; 180,000 RMB; co-investigator

07JCYBJC16500   01/01/2011-12/31/2014 The Mechanism of the role of Mesenchymal Stem Cells on Experimental Autoimmune Uveoretinitis; Tianjin Municipal Science Foundation Grant; 200,000 RMB; PI

30901656   01/01/2010-12/31/2012 The Application of Mesenchymal Stem Cells in Experimental Autoimmune Uveoretinitis; National Natural Science Foundation Grant; 200,000 RMB; PI

11JCZDJC19600   01/01/2007-06/30/2009 The Application of Mesenchymal Stem Cells in Ocular Immunoligical Diseases; Tianjin Municipal Science Foundation Grant; 80,000 RMB; PI
 
CONTACT US
Tianjin Medical University Eye Hospital